ABSTRACT
Objective To study and compare the effects of Fentanyl transdermal pain patches and Pethidine in postoperative analgesia of malignant tumor and its nursing methods.Methods 100 patients with malignant tumor in our hospital from January 2008 to November 2010 were selected as research object,all the patients were randomly divided into group A (Fentanyl transdermal pain patches group) and group B (Pethidine group)with 50 cases in each group,then the VAS score 2,4,8,24 and 48h after the surgery,incidence of adverse reactions,satisfaction rate and serum catecholamine,cortisol,blood glucose before and after the surgery were analyzed and compared,and all the patients were given corresponding nursing measures.Results The VAS score of group A at 2,4,8,24 and 48h after the surgery were all better than those of group B,incidence of adverse reactions was lower than that of group B,satisfaction rate was higher than that of group B,serum catecholamine,cortisol,blood glucose after the surgery were all lower than those of group B,there were significant differences.Conclusions The effects of Fentanyl transdermal pain patches in postoperative analgesia of malignant tumor is stable,and it gets good reputation from the patients,the effects is obvious combined with nursing.
ABSTRACT
Objective To investigate the effects of L-glutamine-supplemented parenteral nutritional sup- port on nutritional status, immunity, and inflammatory response in patients with lung cancer following radical opera- tion. Methods Forty-two malnourished patients with lung malignancies who had undergone radical operations were randomly divided into PN plus group (n =22) and PN group (n = 20). From day 1 to day 5 after operations, parenteral nutrients with the non-proteinic calorfic value of 90 kJ · kg-1 d-1 and nitrogen 0.25 g · kg-1 d-1 were given. From day 2, liquid diets were provided to both groups, and L-glutamine particles (30 g) were provided to PN plus group. Peripheral blood specimens were collected before operation, on day 1, and on day 7 after the oper- ations to determine the serum levels of albumin, prealbumin, transferrin, T lymphocyte subgroup 3 (CD3), CD4, CD8, CD4/CD8, immunoglobulin A (IgA), IgG, IgM, and C-reactive protein. Results The levels of the serum transferrin [(2.29±0.34) vs. (2.15±0.42) g/L], prealbumin [ (0. 27±0.76) vs. (0.23±0. 84) g/L], CD4 (30.9%±2.2% vs. 28.9%±2. 3% ), CD4/CD8 (1.17±0.19 vs. 1.10±0. 81), IgG [(12. 94 2.08) vs. (11. 19±1. 95) g/L] were all significantly higher in the PN plus group than those in PN group on day 7 (P <0. 05) . The level of serum C-reactive protein was significantly lower in PN plus group than that in PN group on day 7 [(31.6±16.7) vs. (36.5±13.3) mg/L, P<0.05]. Conclusion Postoperative L-glutamine-supplemented parenteral nutrition support can improve the nutritional status and immune function and reduce the acute inflammatory response in patients with lung cancer.